Sporadic and familial neuromuscular conditions marked by a surplus of proteins present in a granular or filamentous form, such as desmin-related myopathies, actinopathy and, perhaps, hyaline body myopathy.

 desminopathies: mutations in the desmin and alpha-B crystallin genes
 actinopathy: mutations in the actin gene
 surplus sarcoplasmic and/or intranuclear nemaline bodies

• mutation in tropomyosin-3
• mutation in actin
• mutation in nebulin

References

 Goebel HH, Warlo IA. Surplus protein myopathies. Neuromuscul Disord. 2001 Jan;11(1):3-6. PMID: #11166159#

 Goebel HH, Warlo I. Gene-related protein surplus myopathies. Mol Genet Metab. 2000 Sep-Oct;71(1-2):267-75. PMID: #11001821#