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PML

 

Pathology

-  PML gene is fused to the RARalpha gene in the vast majority of acute promyelocytic leukemias (APL) (PML/RARA fusion gene)

-  PML protein expression is frequently lost in human cancers of various histologic origins, and its loss associates with tumor grade and progression in some tumor histotypes (#14970276#)


Regulation of transcriptional activity by PML - From Biocarta

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