Synopsis

 veinous intimal fibrosis

Etiology

 familial pulmonary veno-occlusive disease (#7129408#)
 post-chemotherapy

• bleomycin (#6199283#)

Associations

 pulmonary arterial occlusive disease (arterial intimal fibrosis) (#4043952#)

Ultrastructure (#6341208#)

 occluded pulmonary veins

• intact endothelial cells
• haphazard proliferation of collagen fibrils and smooth muscle cells

 alveolar capillaries

• thickening of the endothelial cell basement membrane
• increase in the number of cytoplasmic processes of pericytes
• electron-dense deposits located within the thickened basement membrane (considered to represent disintegrating extravasated erythrocytes rather than immune complexes)

References

 Carrington CB, Liebow AA. Pulmonary veno-occlusive disease. Hum Pathol. 1970 Jun;1(2):322-4. PMID: #5521729#