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post-allograft vasculopathy of small muscular arteries

 

Synopisis

Vascular changes in small muscular arteries

-  concentric intimal or medial hyperplasia with luminal narrowing
-  prominent myxoid change of the vascular wall
-  extravasated red blood cells
-  some foamy histiocytes with no evidence of thrombotic microangiopathy

Complications

-  intestinal ischemia
-  pulmonary diffuse alveolar damage (DAD) with hemorrhage

References

-  Selby DM, Rudzki JR, Bayever ES, Chandra RS. Vasculopathy of small muscular arteries in pediatric patients after bone marrow transplantation. Hum Pathol. 1999 Jul;30(7):734-40. PMID: #10414490#



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