Definition: Subtype of intermediate filament inclusions seen in a variety of liver diseases. Mallory bodies contain keratin-8 (KRT8) and keratin-18 (KRT18).

Etiology

 alcoholic liver disease

• alcoholic hepatitis

 primary biliary cirrhosis

Immunochemistry

 ubiquitin + (#11338474#, #2462130#)

References

 Fickert P, Trauner M, Fuchsbichler A, Stumptner C, Zatloukal K, Denk H. Mallory body formation in primary biliary cirrhosis is associated with increased amounts and abnormal phosphorylation and ubiquitination of cytokeratins. J Hepatol 2003;38:387-394.

 Denk H, Stumptner C, Zatloukal K. Mallory bodies revisited. J Hepatol 2000;32:689-702.

 Jensen K, Gluud C. The Mallory body: morphological, clinical and experimental studies (Part 1 of a literature survey). Hepatology. 1994 Oct;20(4 Pt 1):1061-77. PMID: #7927209#

 Worman HJ. Cellular intermediate filament networks and their derangement in alcoholic hepatitis. Alcohol Clin Exp Res. 1990 Dec;14(6):789-804. PMID: #2088113#

 French SW. Present understanding of the development of Mallory's body. Arch Pathol Lab Med. 1983 Sep;107(9):445-50. PMID: #6192789#