Classification

 embryonal carcinoma
 seminoma
 yolk sac tumor
 choriocarcinoma
 teratomas

• mature teratoma
• immature teratoma

According to the localization

 gonadal germ cell tumors

• ovarian germ cell tumor
• testicular germ cell tumor

 extragonadal germ cell tumors

• intracranial germ cell tumors
• mediastinal germ cell tumors

According to the sex or sex of the patient

 male germ cell tumors
 female germ cell tumors
 neonatal germ cell tumors

Associations

 malignant transformation

• embryonal rhabdomyosarcoma in a testicular germ cell tumor
• Wilms tumor arising in a testicular germ cell tumor (#15105660#)
• adenocarcinoma
• primitive neuroectodermal tumor (pPNET)
• acute monoblastic leukemia
• malignant lymphoma

Cytogenetics

 i(12)p

• 90% of adult patients (all histologic subtypes - gonadal and extragonadal localization) (#2177638#)
• few i(12)p in pediatric patients (#11528555#)

 recurring complex chromosomal translocations t(6p21), t(6p22), t(6q23), and t(11q13) (#8174069#)

 constitutional translocation t(12q13) (#12752256#)

CGH (#15880464#)

Expression profile: #14595015#

References

 Sperger JM, Chen X, Draper JS, Antosiewicz JE, Chon CH, Jones SB, Brooks JD, Andrews PW, Brown PO, Thomson JA. Gene expression patterns in human embryonic stem cells and human pluripotent germ cell tumors. Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13350-5. Epub 2003 Oct 31. PMID: #14595015#

 Chaganti RS, Houldsworth J. Genetics and biology of adult human male germ cell tumors. Cancer Res. 2000 Mar 15;60(6):1475-82. PMID: #10749107#