pancreatic acinar cell carcinoma

Differential diagnosis

pancreatic endocrine tumors
solid-pseudopapillary tumors
pancreatoblastoma
ductal adenocarcinoma
acinar cell adenoma
focal acinar cell transformation
microglandular carcinoma

Variants

mixed acinar-endocrine carcinoma of the pancreas (#15290275#)

Molecular biology

frequent allelic loss on chromosome 11p (50%)
alterations in the APC/beta-catenin pathway (23.5%)

Allelotype: #11072247#

1p36.31	4q26-31.1	17p13	11q	13q	15q15-22.1	3q	6q	8q	18q	21q
>70%	>70%	>70%	60%-70%	60%-70%	60%-70%	50%-60%	50%-60%	50%-60%	50%-60%	50%-60%

CGH (comparative genomic hybridization): #10862035#

gains	1q42	12p11.2	Xq12-21
losses	16p13.2-p13.1	16q23

Pancreatic acinar cell carcinoma

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