Function

 marker of human cytotoxic effector cells
 Two novel fully functional isoforms of CX3CR1 are potent HIV coreceptors (#14607932#)

 The lamina propria dendritic cells of the small intestine actively sample gut bacteria through the formation of transepithelial dendrites by a mechanism that is dependent on the expression of the chemokine receptor CX3CR1.

References

 Foti M, Ricciardi-Castagnoli P. Antigen sampling by mucosal dendritic cells. Trends Mol Med. 2005 Sep;11(9):394-6. PMID: #16087403#