Yolk sac tumor accounts for more than 80% of testicular germ cell tumors in children. It displays an amazing variety of architectural patterns.

Architectural patterns

 Schiller-Duvall bodies
 hyaline globules

 microcystic pattern: interconnecting cords and ribbons of tumor cells are surrounded by abundant myxoid stroma

 myxomatous pattern: neoplastic stellate, spindle, or epithelioid cells in abundant myxoid stroma. Many of these cells are pluripotential and can form skeletal muscle, cartilage, and bone. Such areas should not be confused with teratoma

 hepatoid pattern (20%)

• sheets of polygonal cells with abundant eosinophilic cytoplasm
• hyaline globules
• bile canaculi

 solid pattern

• sheets of uniform tumor cells with clear or pale pink cytoplasm
• differentgial diagnosis: seminoma

Localization

 ovarian yolk sac tumor

CGH (#15880464#)