The dystrophin-glycoprotein complex (DGC) connects the extracellular matrix to the cytoskeleton in skeletal muscle and many other tissues.
Dystroglycan (DG) is an adhesion molecule composed of two subunits, alpha and beta, that are produced by the post-translational cleavage of a single precursor molecule. DG is a pivotal component of the dystrophin-glycoprotein complex.