Clathrin is a structural protein found in coated pits and vesicles, organelles which are important in membrane trafficking functions such as endocytosis and Golgi sorting.

Pathology

 fusion gene in inflammatory myofibroblastic tumors (IMF)

Features

 clathrin-coated vesicles
 clathrin-coated pits
 clathrin-mediated endocytosis
 clathrin adaptator proteins

References

 Brooksbank C. Endocytosis. Tent pegs for clathrin. Nat Rev Mol Cell Biol. 2001 Mar;2(3):166. PMID: #11265244#

 McPherson PS. The endocytic machinery at an interface with the actin cytoskeleton: a dynamic, hip intersection. Trends Cell Biol. 2002 Jul;12(7):312-5. PMID: #12185847#

 Dell'Angelica EC. Clathrin-binding proteins: got a motif? Join the network. Trends Cell Biol. 2001 Aug;11(8):315-8. PMID: #11489622#