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ETSs

ETS-family transcription factors, ETS transcription factors

 

The ETS proteins are transcription factors which activate transcription by interaction with purine-rich sequences present in the promoter/enhancer region of the TCRA gene (MIM.186880).

Members

ETS1 ETS2 FLI1 ERG ELK1 ELK2 FEV

The several classes of ETS family members could be due to an ancestral gene duplication, followed by genetic recombination(s) or divergence. Since all of the classes are present in both invertebrates and vertebrates, such an ancestral duplication must predate the emergence of chordates more than 500 million years ago.


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