Synopsis

 chronic inflammatory infiltrate (Grade 1)
 lamina propria neutrophils and eosinophiles (Grade 2)
 neutrophils in epithelium (Grade 3)
 crypt destruction (Grade 4)
 mucosal ulceration or ulceration (Grade 5)
 colonic inflamatory pseupolyp

Associations

 backwash ileitis
 postcolectomy pouchitis
 diffuse duodenitis (#11023103#)

Complications

 colonic adenoma
 dysplasia-associated lesion or mass (DALM)
 ulcerative colitis-associated colorectal adenocarcinoma

Differential diagnosis

 colonic Crohn disease

References

 Tsang P, Rotterdam H. Biopsy diagnosis of colitis: possibilities and pitfalls.Am J Surg Pathol 1999 Apr;23(4):423-30

 Kleer CG, Appelman HD. Ulcerative colitis: patterns of involvement in colorectal biopsies and changes with time.Am J Surg Pathol 1998 Aug;22(8):983-9

Variants

 steroid-refractory ulcerative colitis

• association with CMV infection (#15104299#)

References

 Sandle GI. Pathogenesis of diarrhea in ulcerative colitis: new views on an old problem. J Clin Gastroenterol. 2005 Apr;39(4 Suppl 2):S49-52. PMID: #15758659#

 Podolsky DK. Inflammatory bowel disease. N Engl J Med. 2002 Aug 8;347(6):417-29. PMID: #12167685#

 Price AB, Morson BC. Inflammatory bowel disease: the surgical pathology of Crohn's disease and ulcerative colitis. Hum Pathol. 1975 Jan;6(1):7-29. PMID: #1089084#