Synopsis

Immunochemistry

 smooth muscle actin+ (SMA+)
 BCL2+
 cyclin D1+/-
 CD44 (50 to 80%)
 GLUT+ (25-50%)

• Glut1 positivity closely correlated with aggressive biologic behavior reflected by distant metastatic spread.

Localization

 cutaneous leiomyosarcoma
 subcutaneous leiomyosarcoma
 deep leiomyosarcoma (soft tissues leiomyosarcoma)
 retroperitoneal leiomyosarcoma
 vascular leiomyosarcoma
 uterine leiomyosarcoma
 gastrointestinal leiomyosarcoma
 leiomyosarcoma of external genitalia (vulva, penis) (#14707873#)

Cytogenetics

 Most karyotypes are complex and no consistent aberrations.

CGH (#12920222#)

losses	10q	13q14-q21	17p	19p
gains	1q	5p14-pter	17p

LOH

 3p LOH (#12839673#)
 9p LOH (9p21 LOH) (#15731925#)
 Chr.10 LOH (#10079273#)

Differential diagnosis

 fusiform cell tumors

• smooth muscle cell tumors
• myofibroblastic tumors

 EBV-associated smooth muscle tumors

• EBV-associated leiomyoma
• EBV-associated leiomyosarcoma

See also

 smooth muscle tumors

• EBV-associated smooth muscle tumors
  • EBV-associated leiomyoma
  • EBV-associated leiomyosarcoma

References

 Rao UN, Finkelstein SD, Jones MW. Comparative immunohistochemical and molecular analysis of uterine and extrauterine leiomyosarcomas. Mod Pathol. 1999 Nov;12(11):1001-9. PMID: #10574596#