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adenomatoid tumor

 
Adenomatoid tumor is a benign, relatively rare neoplasm occurring primarily in the genital tract of both genders.

Localization

-  epididymis
-  tunica albuginea
-  testicule
-  ovary
-  myometrium
-  fallopian tube
-  parafallopian region
-  mediastinum (#14707875#)
-  adrenal gland (#14506647#)

Synopsis

-  cystic spaces lined by flattened or cuboidal epithelial cells
-  walls of the cysts: proliferation of small canalicular structures lined by round to polygonal epithelioid cells with vacuolated eosinophilic cytoplasm
-  +/- infarction (#14707867#)
-  fibrous tissue
-  numerous slit-like and pseudotubular spaces
-  thread-like bridging strands crossing the pseudotubular spaces (#14571427#)

Immunohistochemistry

-  AE1/AE3 cytokeratin+
-  CK5/CK6 cytokeratin+
-  calretinin+
-  CK7-
-  CK20-
-  alpha-fetoprotein-
-  CD31-
-  carcinoembryonic antigen-
-  MOC-31-
-  chromogranin-

Electron microscopy

-  numerous long microvilli on the cell surface and abundant tonofilaments/desmosomal plaques in the tumor cells, characteristic of mesothelial cells



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