peroxisomes
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Peroxisomes import folded, even oligomeric, proteins, which distinguishes the peroxisomal translocation machinery from the well-characterized translocons of other organelles.
Like other subcellular organelles, peroxisomes divide and segregate to daughter cells during cell division, but this organelle can also proliferate or be degraded in response to environmental cues.
Although the mechanisms and genes involved in these processes are still under active investigation, an important player in peroxisome proliferation is a dynamin-related protein (DRP) that is recruited to the organelle membrane by a DRP receptor.
Related DRPs also function in the division of mitochondria and chloroplasts. Many other proteins and signals regulate peroxisome division and proliferation.
Pathology
peroxisomes biogenesis disorders (MIM.601359)
See also
peroxisome proliferator-activated receptors (PPARs)
References
Yan M, Rayapuram N, Subramani S. The control of peroxisome number and size during division and proliferation. Curr Opin Cell Biol. 2005 Aug;17(4):376-83. PMID: 15978793
Erdmann R, Schliebs W. Peroxisomal matrix protein import: the transient pore model. Nat Rev Mol Cell Biol. 2005 Sep;6(9):738-42. PMID: 16103872
Titorenko VI, Rachubinski RA. The life cycle of the peroxisome. Nat Rev Mol Cell Biol. 2001 May;2(5):357-68. PMID: 11331910
Titorenko VI, Rachubinski RA. Dynamics of peroxisome assembly and function. Trends Cell Biol. 2001 Jan;11(1):22-29. PMID: 11146295
Pap EH, Dansen TB, Wirtz KW. Peptide-based targeting of fluorophores to peroxisomes in living cells. Trends Cell Biol. 2001 Jan;11(1):10-12. PMID: 11146278
