| Pubmed | emedicine | OMIM | NORD | Web | Ggl Images | Yho Images | Videos |

HHV6

Human Herpes Virus type 6, HHV-6

 

Herpesvirus 6 (HHV-6) is a ubiquitous virus known to cause febrile syndromes and exanthema subitum in children. Less commonly, and particularly in organ transplant recipients, it may result in hepatitis, bone marrow suppression, interstitial pneunonitis, and meningoencephalitis.

Pathology

-  HHV6-associated hepatitis
-  HHV6-associated myocarditis (#11577130#)
-  HHV6-associated bone marrow suppression
-  HHV6-associated interstitial pneunonitis
-  HHV6-associated meningoencephalitis
-  HHV6-associated gastroduodenitis (immunosuppressed individuals)
-  HHV6-associated pancreatitis (immunosuppressed individuals)

Synopsis

-  cytopathic effect

-  electron microscopy

-  polymerase chain reaction

-  Serology

Predisposition

-  immunosuppression

. Thus, HHV-6 variant A can cause gastroduodenitis and pancreatitis in . Multinucleate giant cells and enveloped virions with a prominent tegument can be used as morphologic criteria to raise the possibility of HHV-6 infection in human biopsy tissue.

Pathology

-  HHV6-associated hepatitis

References

-  Aita K, Jin Y, Irie H, Takahashi I, Kobori K, Nakasato Y, Kodama H, Yanagawa Y, Yoshikawa T, Shiga J. Are there histopathologic characteristics particular to fulminant hepatic failure caused by human herpesvirus-6 infection? A case report and discussion. Hum Pathol. 2001 Aug;32(8):887-9. PMID: #11521236#

-  Tao Q, Ambinder RF. Lack of Kaposi's sarcoma-associated virus (KSHV) and detection of human herpes virus 6 and 7 by PCR in African Burkitt's lymphoma from HIV-negative patients. Hum Pathol. 1999 Oct;30(10):1269-70. PMID: #10534180#

-  Hoang MP, Dawson DB, Rogers ZR, Scheuermann RH, Rogers BB. Polymerase chain reaction amplification of archival material for Epstein-Barr virus, cytomegalovirus, human herpesvirus 6, and parvovirus B19 in children with bone marrow hemophagocytosis. Hum Pathol. 1998 Oct;29(10):1074-7. PMID: #9781644#

-  Carbone A, Dolcetti R, Gloghini A, Maestro R, Vaccher E, di Luca D, Tirelli U, Boiocchi M. Immunophenotypic and molecular analyses of acquired immune deficiency syndrome-related and Epstein-Barr virus-associated lymphomas: a comparative study. Hum Pathol. 1996 Feb;27(2):133-46. PMID: #8617454#

-  Kempf W, Adams V, Pfaltz M, Briner J, Schmid M, Moos R, Hassam S. Human herpesvirus type 6 and cytomegalovirus in AIDS-associated Kaposi's sarcoma: no evidence for an etiological association. Hum Pathol. 1995 Aug;26(8):914-9. PMID: #7635454#

-  Vinters HV, Wang R, Wiley CA. Herpesviruses in chronic encephalitis associated with intractable childhood epilepsy. Hum Pathol. 1993 Aug;24(8):871-9. PMID: #8397159#



Forum de l'article

Contact us at humpath2004@yahoo.ca if you want to be the curator of this page or this section.
Copyright www.humpath.com