Localization

 digestive Crohn disease

• gastric Crohn disease (Crohn gastritis)
• intestinal Crohn disease and ileal Crohn disease (Crohn ileitis)
• colorectal Crohn disease and colonic Crohn disease

 pulmonary Crohn disease
 skin (cutaneous Crohn disease) (#14652821#)

• pyoderma gangrenosum
• erythema nodosum (septal panniculitis)
• metastatic Crohn's disease
• neutrophilic lobular panniculitis (#11305385#)

Genetic susceptibility

 Locus IBD5 at 5q31: CARD15 mutations

 Locus IBD5 at 5q31: variations in SLC22A4 in the organic cation transporter cluster (OCTN) (#15107849#)

 Locus IBD5 at 5q31: variations in SLC22A5 in the organic cation transporter cluster (OCTN) (#15107849#)

References

 Schreiber S, Rosenstiel P, Albrecht M, Hampe J, Krawczak M. Genetics of Crohn disease, an archetypal inflammatory barrier disease. Nat Rev Genet. 2005 May;6(5):376-88. PMID: #15861209#

 Russell RK, Nimmo ER, Satsangi J. Molecular genetics of Crohn's disease. Curr Opin Genet Dev. 2004 Jun;14(3):264-70. PMID: #15172669#

 Pizarro TT, Arseneau KO, Bamias G, Cominelli F. Mouse models for the study of Crohn's disease. Trends Mol Med. 2003 May;9(5):218-22. PMID: #12763527#

 Podolsky DK. Inflammatory bowel disease. N Engl J Med. 2002 Aug 8;347(6):417-29. PMID: #12167685#

 Elson CO. Genes, microbes, and T cells--new therapeutic targets in Crohn's disease. N Engl J Med. 2002 Feb 21;346(8):614-6. PMID: #11856802#