cutaneous Rosai-Dorfman disease
Rosai-Dorfman disease (RDD), previously known as sinus histiocytosis with massive lymphadenopathy, is a benign, idiopathic histiocytic proliferative disorder.
Synopsis
solitary nodules
large, well-circumscribed plaque
large, pale, histiocytic cells (Rosai-Dorfman cells) exhibiting cytophagocytosis
Immunohistochemistry
S-100+
CD68+
CD1a-
Electron microscopy
Birbeck granules are absent
References
Pitamber HV, Grayson W. Five cases of cutaneous Rosai-Dorfman disease. Clin Exp Dermatol. 2003 Jan;28(1):17-21. PMID: #12558621#
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