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generalized eruptive histiocytosis

 
Generalized eruptive histiocytosis belongs to the cutaneous non-Langerhans cell histiocytoses and is a rare monocyte-macrophage proliferative disorder that usually follows a benign clinical course.

Synopsis

-  erythematous macules and slightly elevated papules widely distributed over the trunk, neck, face, and thighs
-  diffuse histiocytic infiltrate in the skin

Ultrastructurally

-  no Birbeck granules

Immunochemistry

-  S-100-
-  CD1a-
-  MS-1 high molecular weight protein + (highly characteristic for cutaneous non-Langerhans cell histiocytoses)

Associations

-  acute monocytic leukemia (#14576638#)


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