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CD117

c-kit

 

The proto-oncogene c-kit is a receptor tyrosine kinase recognized to initiate essential signal transduction pathways that transmit biological signals for cellular proliferation, differentiation, and metastasis. Aberrant expression or mutation of c-kit has been shown to be involved in the pathogenesis of many cancers.

Pathology

-  germline mutations

-  somatic mutations

-  overexpression in tumors

Diagnostic use

-  positive diagnosis of renal oncocytoma (71%) (#15105658#)
-  positive diagnosis of renal chromophobe renal cell carcinoma (88%) (#15105658#)

References

-  Druker BJ. STI571 (Gleevec) as a paradigm for cancer therapy. Trends Mol Med. 2002;8(4 Suppl):S14-8. PMID: #11927282#



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