Cytogenetics

 cytogentical anomalies in 50% of cases of myelodysplastic syndrome (MDS) and 80% of cases of secondary MDS (following chemotherapy or radiotherapy)
 partial or complete chromosome deletion or addition

• del5q
• -7
• +8
• -Y
• del20q

 balanced translocations

• MDS1-EVI1 in t(3;3) or t(3;21) translocations
• TEL in t(5;12)
• HIP1 in t(5;7)
• MLF1 in t(3;5)
• MEL1 in t(1;3)

References

 Fenaux P. Chromosome and molecular abnormalities in myelodysplastic syndromes. Int J Hematol. 2001 Jun;73(4):429-37. PMID: #11503956#