Synopsis

 pleomorphic histiocytic cells: medium cells, large cells and the giant cells expressing CD68, lysozyme and S100 protein.
 erythrophagocytosis (erythrophagocytic histiocytosis)
 lymphocytophagocytosis

Forms

 localized forms (localized histiocytic sarcoma)

• spleen
• central nervous system (#12548175#)

 systemic forms (systemic histiocytic sarcoma)

Immunochemsitry

 CD11+
 CD13+
 HLA-DR+
 CD33+
 lysozyme+
 S-100+

Associations

 histiocytic sarcoma following allogeneic bone marrow transplantation for T-ALL (#14513060#)

References

 Audouin J, Vercelli-Retta J, Le Tourneau A, Adida C, Camilleri-Broet S, Molina T, Diebold J. Primary histiocytic sarcoma of the spleen associated with erythrophagocytic histiocytosis. Pathol Res Pract. 2003;199(2):107-12. PMID: #12747473#

 Boisseau-Garsaud AM, Vergier B, Beylot-Barry M, Nastasel-Menini F, Dubus P, de Mascarel A, Eghbali H, Beylot C. Histiocytic sarcoma that mimics benign histiocytosis. J Cutan Pathol. 1996 Jun;23(3):275-82. PMID: #8793665#