CARDs are a family of intracellular proteins that contain an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and a C-terminal regulatory domain.

Members

Function

Proteins containing CARD, or related DD or DED, motifs are centrally involved in assembling protein complexes that drive activation of either IkappaB kinase or caspases by facilitating intermolecular juxtapositioning.

CARD-family proteins occupy crucial positions in divergent stress-associated signalling pathways that culminate in inflammatory responses or apoptosis.

Pathology

References

 Martin SJ. Dealing the CARDs between life and death. Trends Cell Biol. 2001 May;11(5):188-9. PMID: #11393153#