Function

Lamellipodia, filopodia and membrane ruffles are essential for cell motility, the organization of membrane domains, phagocytosis and the development of substrate adhesions.

Their formation relies on the regulated recruitment of molecular scaffolds to their tips (to harness and localize actin polymerization), coupled to the coordinated organization of actin filaments into lamella networks and bundled arrays.

Their turnover requires further molecular complexes for the disassembly and recycling of lamellipodium components.

References

Wehrle-Haller B, Imhof B. The inner lives of focal adhesions. Trends Cell Biol. 2002 Aug ;12(8):382-9. PMID : #12191915#

Small JV, Stradal T, Vignal E, Rottner K. The lamellipodium : where motility begins. Trends Cell Biol. 2002 Mar ;12(3):112-20. PMID : #11859023#