Posttransplantation lymphoproliferative disorders (PTLDs) eventually occur in approximately 5% of all organ transplant recipients. Most of cases are B-cell proliferations associated with the Epstein-Barr virus (EBV). T-cell PTLDs are relatively rare.
Types
early PTLDs
polymorphic PTLDs (polymorphic B-cell hyperplasia)
monomorphic PTLDs
Variants
polymorphic PTLDs
monomorphic PTLDs
Localization
lymph nodes
gastrointestinal tract (#2158245#)
renal allograft (#8619421#)
sites of previous surgical intervention (#12698104#)
Types (Knowles et al., 1995)
plasmacytic hyperplasia and plasmacytic malignancy (#11860313#)
polymorphic B-cell hyperplasia and polymorphic B-cell lymphoma
immunoblastic lymphoma and multiple myeloma
Variants
Epstein-Barr virus-negative post-transplant lymphoproliferative disorders (#10716151#)
See also
References
Chadburn A, Chen JM, Hsu DT, Frizzera G, Cesarman E, Garrett TJ, Mears JG, Zangwill SD, Addonizio LJ, Michler RE, Knowles DM. The morphologic and molecular genetic categories of posttransplantation lymphoproliferative disorders are clinically relevant. Cancer. 1998 May 15;82(10):1978-87. PMID: #9587133#
Chadburn A, Cesarman E, Knowles DM. Molecular pathology of posttransplantation lymphoproliferative disorders. Semin Diagn Pathol. 1997 Feb;14(1):15-26. PMID: #9044506#
Knowles DM, Cesarman E, Chadburn A, Frizzera G, Chen J, Rose EA, Michler RE. Correlative morphologic and molecular genetic analysis demonstrates three distinct categories of posttransplantation lymphoproliferative disorders. Blood. 1995 Jan 15;85(2):552-65. PMID: #7812011#