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PTLDs

post-transplantation lymphoproliferative disorders, post-transplantation lymphoproliferative disorders

 

Posttransplantation lymphoproliferative disorders (PTLDs) eventually occur in approximately 5% of all organ transplant recipients. Most of cases are B-cell proliferations associated with the Epstein-Barr virus (EBV). T-cell PTLDs are relatively rare.

Types

-  early PTLDs

-  polymorphic PTLDs (polymorphic B-cell hyperplasia)

-  monomorphic PTLDs

Variants

-  polymorphic PTLDs
-  monomorphic PTLDs

Lymphomas

Localization

-  lymph nodes
-  gastrointestinal tract (#2158245#)
-  renal allograft (#8619421#)
-  sites of previous surgical intervention (#12698104#)

Types (Knowles et al., 1995)

-  plasmacytic hyperplasia and plasmacytic malignancy (#11860313#)
-  polymorphic B-cell hyperplasia and polymorphic B-cell lymphoma
-  immunoblastic lymphoma and multiple myeloma

Variants

-  Epstein-Barr virus-negative post-transplant lymphoproliferative disorders (#10716151#)

See also

-  EBV-associated tumors

References

-  Chadburn A, Chen JM, Hsu DT, Frizzera G, Cesarman E, Garrett TJ, Mears JG, Zangwill SD, Addonizio LJ, Michler RE, Knowles DM. The morphologic and molecular genetic categories of posttransplantation lymphoproliferative disorders are clinically relevant. Cancer. 1998 May 15;82(10):1978-87. PMID: #9587133#

-  Chadburn A, Cesarman E, Knowles DM. Molecular pathology of posttransplantation lymphoproliferative disorders. Semin Diagn Pathol. 1997 Feb;14(1):15-26. PMID: #9044506#

-  Knowles DM, Cesarman E, Chadburn A, Frizzera G, Chen J, Rose EA, Michler RE. Correlative morphologic and molecular genetic analysis demonstrates three distinct categories of posttransplantation lymphoproliferative disorders. Blood. 1995 Jan 15;85(2):552-65. PMID: #7812011#



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