Localization

 soft tissue
 nerve (intraneural synovial sarcoma) (#14685256#)
 kidney (renal synovial sarcoma)

Variants

 monophasic synovial sarcoma
 with rhabdoid tumoral cells (#14521444#, #15105652#)

Differential diagnosis

 fusiform cell tumors

• fibrosarcomas
  • adult-type fibrosarcoma

Molecular biology

Synovial sarcoma is characterized cytogenetically by the t(X;18)(p11;q11) translocation, resulting in fusion between the SS18 gene on chromosome 18 and one of the SSX genes on the X chromosome.

 SS18/SSX1
 SS18/SSX2
 SS18/SSX4

These three fusion genes account for more than 95% of the synovial sarcomas.

 SS18L1/SSX1 (#12696068#)

See also

 Tumors

• Sarcomas
• fusiform cell tumors
• biphasic tumors
• synovial tumors