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intersex disorders

intersexuality, sexual ambiguity

 

Chromosomal classifcation

-  XY intersex
-  XX intersex

Morphological classification

-  true hermaphrodism
-  MGD
-  pseudohermaphrodisms
-  male pseudohermaphrodism
-  female pseudohermaphrodism

References

-  MacLaughlin DT, Donahoe PK. Sex determination and differentiation. N Engl J Med. 2004 Jan 22;350(4):367-78. PMID: #14736929#

-  Vaiman D, Pailhoux E. Mammalian sex reversal and intersexuality: deciphering the sex-determination cascade. Trends Genet. 2000 Nov;16(11):488-94. PMID: #11074290#

-  Behrman: Nelson Textbook of Pediatrics, 16th ed., Chapter 598 - Hermaphroditism (Intersexuality), p. 1760-1767. Cotinot C, Pailhoux E, Jaubert F, Fellous M. Molecular Genetics of Sex Determination, Seminars in Reproductive Medicine, 2002; p. 157-168.

-  Hutcheson J. Ambiguous Genitalia and Intersexuality, eMedicine Journal, 2002, 3(8); p.1-25.

-  McGregor L et al. Fraser syndrome and mouse blebbed phenotype caused by mutations in FRAS1/Fras1 encoding a putative extracellular matrix protein, Nature Genetics, 2003, 34(2); p. 203-208.

-  Sultan C, Paris F, Jeandel C, Lumbroso S, Benoît Galifer R. Ambiguous Genitalia in the Newborn, Seminars in Reproductive Medicine, 2002; p. 181-188.

Books

-  Oxford Medical Databases

-  London Dysmorphology Database

-  Potter's Pathology of the Fetus and Infant, Chapter 27 - Reproductive System, editor Enid Gilbert-Barness, p. 1202-1241.

-  Walsh: Campbell's Urology, 8th ed., Chapter 68 - Sexual Differentiation: Normal and Abnormal, 2002, p. 2395-2423.


Hermaphrodism: Association of a streak ovotestis (left) and testis (right)

Hermaphrodism (22 weeks) - Association of a left pvary and a right testis

DIagnsotic algorythm of intersex disorders

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