Etiology

 familial Mediterranean fever (FMF) (MIM.249100) is caused by mutation in the pyrin gene (MEFV) (MIM.608107)
 autosomal dominant periodic fever is caused by mutations in the tumor necrosis factor receptor-1 gene (TNFRSF1A) (MIM.191190)

References

 McDermott MF. Genetic clues to understanding periodic fevers, and possible therapies. Trends Mol Med. 2002 Dec;8(12):550-4. PMID: #12470987#

 Drenth JP, van der Meer JW. Hereditary periodic fever. N Engl J Med. 2001 Dec 13;345(24):1748-57. PMID: #11742050#

 Centola M, Aksentijevich I, Kastner DL. The hereditary periodic fever syndromes: molecular analysis of a new family of inflammatory diseases. Hum Mol Genet. 1998;7(10):1581-8. PMID: #9735379#