Functions

 The Rb/E2F pathway is critical in regulating the initiation of DNA replication.

 The pathway controls the activity of the retinoblastoma tumor suppressor protein (RB), which in turn regulates the E2F transcription factor.

 The Rb/E2F pathway is critical in regulating the initiation of DNA replication.

 The control of the Rb/E2F pathway is disrupted in virtually all human cancers.

References

 Korenjak M, Brehm A. E2F-Rb complexes regulating transcription of genes important for differentiation and development. Curr Opin Genet Dev. 2005 Oct;15(5):520-7. PMID: #16081278#

 Nevins JR. The Rb/E2F pathway and cancer. Hum Mol Genet. 2001 Apr;10(7):699-703. PMID: #11257102#