Functions

 regulating beta-catenin, an important mediator of cell adhesion and a transcriptional activator.
 cytoskeletal regulation

Pathology

 germline mutations of APC in

• familial adenomatous polyposis
• Gardner syndrome
• medulloblastoma-associated Turcot syndrome

 truncation mutations in the adenomatous polyposis coli protein (APC) are responsible for familial and sporadic colonic tumours

See also

 WNT signaling pathway
 cadherin-catenin complex

References

 Fearnhead NS, Britton MP, Bodmer WF. The ABC of APC. Hum Mol Genet. 2001 Apr;10(7):721-33. PMID: #11257105#

 Dikovskaya D, Zumbrunn J, Penman GA, Nathke IS. The adenomatous polyposis coli protein: in the limelight out at the edge. Trends Cell Biol. 2001 Sep;11(9):378-84. PMID: #11514192#