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EWS

MIM.133450 22q12

 

Fusion genes

EWS/FLI1 t(11;22)(q24;q12) Ewing sarcoma
ERG/EWS t(21;22)(q22;q12) Ewing sarcoma
ETV1/EWS t(7;22)(p22;q12) Ewing sarcoma
E1AF/EWS t(17;22)(q12;q12) Ewing sarcoma
EWS/FEV t(2;22)(q13;q12) Ewing sarcoma
ATF1/EWS t(12;22)(q13;q12) malignant melanoma of soft parts (clear cell sarcoma)
EWS/TEC t(9;22)(q22;q12) extraskeletal myxoid chondrosarcoma
ETV4/EWS t(17;22)(q12;q12) undifferentiated sarcoma of infancy
EWS/CHOP t(12;22)(q13;q12) myxoid liposarcoma
EWS/WT1 t(11;22) desmoplastic small round cell tumor (DSRCT)

Pathology

-  EWS/ATF1 fusion gene by a t(12;22)(q13;q12) in clear cell sarcoma (soft part melanoma)
-  EWS/ETV4 fusion gene by at(17;22)(q12;q12) in undifferentiated sarcoma of infancy (#8834175#)

-  EWS at AGCOH

EWS partners in fusion genes - From AGCOH

EWS protein role - (From Pr Heinz Gehring)

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