complexes associated with the myofibrillar protein titin sense myocyte stretch.
mutations in the tibial muscular dystrophy (MIM.600334) (#12145747#)
mutations in dilated cardiomyopathy
References
Miller MK, Granzier H, Ehler E, Gregorio CC. The sensitive giant: the role of titin-based stretch sensing complexes in the heart. Trends Cell Biol. 2004 Mar;14(3):119-26. PMID: #15003620#
Hein S, Schaper J. Weakness of a giant: mutations of the sarcomeric protein titin. Trends Mol Med. 2002 Jul;8(7):311-3. PMID: #12114104#