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asthma

 

Asthma is a chronic respiratory condition that affects children and adults. Genetic predisposition and environmental factors interact to produce the disease.

Types

-  acute asthma
-  chronic asthma

Susceptibility

-  5q31-33: IL12B (#15322986#)
-  6p21
-  IL13 (TH2 cytokine signaling pathway)
-  ADAM33
-  DPP10 (peptidase gene)
-  PHF11 at 13q14
-  Locus AS1 : 14q24 (#12119603#)
-  Tim1 (mouse)
-  C5

References

-  Kay AB. The role of eosinophils in the pathogenesis of asthma. Trends Mol Med. 2005 Apr;11(4):148-52. PMID: #15823751#

-  Wills-Karp M, Ewart SL. Time to draw breath: asthma-susceptibility genes are identified. Nat Rev Genet. 2004 May;5(5):376-87. PMID: 15143320

-  Weiss ST, Raby BA. Asthma genetics 2003. Hum Mol Genet. 2004 Apr 1;13 Spec No 1:R83-9. PMID: #14764626#

-  Cookson W. A new gene for asthma: would you ADAM and Eve it? Trends Genet. 2003 Apr;19(4):169-72. PMID: #12683965#

-  Cookson WO, Moffatt MF. Genetics of asthma and allergic disease. Hum Mol Genet. 2000 Oct;9(16):2359-64. PMID: #11005790#


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