Asthma is a chronic respiratory condition that affects children and adults. Genetic predisposition and environmental factors interact to produce the disease.
Types
Susceptibility
5q31-33: IL12B (#15322986#)
6p21
IL13 (TH2 cytokine signaling pathway)
ADAM33
DPP10 (peptidase gene)
PHF11 at 13q14
Locus AS1 : 14q24 (#12119603#)
Tim1 (mouse)
C5
References
Kay AB. The role of eosinophils in the pathogenesis of asthma. Trends Mol Med. 2005 Apr;11(4):148-52. PMID: #15823751#
Wills-Karp M, Ewart SL. Time to draw breath: asthma-susceptibility genes are identified. Nat Rev Genet. 2004 May;5(5):376-87. PMID: 15143320
Weiss ST, Raby BA. Asthma genetics 2003. Hum Mol Genet. 2004 Apr 1;13 Spec No 1:R83-9. PMID: #14764626#
Cookson W. A new gene for asthma: would you ADAM and Eve it? Trends Genet. 2003 Apr;19(4):169-72. PMID: #12683965#
Cookson WO, Moffatt MF. Genetics of asthma and allergic disease. Hum Mol Genet. 2000 Oct;9(16):2359-64. PMID: #11005790#