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morphogens

morphogen gradients

 

Morphogen gradients play a pivotal role in most phases of developmental patterning. To ensure proper patterning, reproducible gradients are established under diverse environmental conditions and genetic backgrounds.

-  buffer fluctuations in gene dosage or environmental conditions are reffered as 'robustness'
-  generating the spatial distribution of morphogens

References

-  Kerszberg M. Noise, delays, robustness, canalization and all that. Curr Opin Genet Dev. 2004 Aug;14(4):440-5. PMID: #15261662#

-  Eldar A, Shilo BZ, Barkai N. Elucidating mechanisms underlying robustness of morphogen gradients. Curr Opin Genet Dev. 2004 Aug;14(4):435-9. PMID: #15261661#

-  Kerszberg M. Noise, delays, robustness, canalization and all that. Curr Opin Genet Dev. 2004 Aug;14(4):440-5. PMID: #15261662#

-  Eldar A, Shilo BZ, Barkai N. Elucidating mechanisms underlying robustness of morphogen gradients. Curr Opin Genet Dev. 2004 Aug;14(4):435-9. PMID: #15261661#

-  Tabata T. Genetics of morphogen gradients. Nat Rev Genet. 2001 Aug;2(8):620-30. PMID: #11483986#


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