Members

 presenilin-1
 presenilin-2

References

 Martoglio B, Golde TE. Intramembrane-cleaving aspartic proteases and disease: presenilins, signal peptide peptidase and their homologs. Hum Mol Genet. 2003 Oct 15;12 Spec No 2:R201-6. Epub 2003 Sep 09. PMID: #12966028#

 Van Gassen G, Annaert W. Amyloid, presenilins, and Alzheimer's disease. Neuroscientist. 2003 Apr;9(2):117-26. PMID: #12708616#

 Tandon A, Fraser P. The presenilins. Genome Biol. 2002 Oct 23;3(11):reviews3014. PMID: #12429067#

 Haass C, Steiner H. Alzheimer disease gamma-secretase : a complex story of GxGD-type presenilin proteases. Trends Cell Biol. 2002 Dec ;12(12):556-62. PMID : #12495843#

 Fortini ME. Notch and presenilin: a proteolytic mechanism emerges. Curr Opin Cell Biol. 2001 Oct;13(5):627-34. PMID: #11544033#

 Golde TE, Younkin SG. Presenilins as therapeutic targets for the treatment of Alzheimer's disease. Trends Mol Med. 2001 Jun;7(6):264-9. PMID: #11378516#

 Steiner H, Haass C. Intramembrane proteolysis by presenilins. Nat Rev Mol Cell Biol. 2000 Dec;1(3):217-24. PMID: #11252897#

 Theuns J, Van Broeckhoven C. Transcriptional regulation of Alzheimer's disease genes: implications for susceptibility. Hum Mol Genet. 2000 Oct;9(16):2383-94. PMID: #11005793#

 Sisodia SS, Kim SH, Thinakaran G. Function and dysfunction of the presenilins. Am J Hum Genet. 1999 Jul;65(1):7-12. PMID: #10364510#

 Hutton M, Hardy J. The presenilins and Alzheimer's disease. Hum Mol Genet. 1997;6(10):1639-46. PMID: #9300655#

 Cruts M, Hendriks L, Van Broeckhoven C. The presenilin genes: a new gene family involved in Alzheimer disease pathology. Hum Mol Genet. 1996;5 Spec No:1449-55. PMID: #8875251#