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histiocytic sarcoma

histiocytic lymphoma

 

Microscopical synopsis

-  erythrophagocytic histiocytosis (#12747473#)

Immunochemistry

-  CD68 +
-  lysozyme +
-  alpha-1-antitrypsin +
-  CD45 +
-  CD45RO +
-  CD1a +
-  S-100 - or + (#9808131#, #12747473#)

References

-  Hornick JL, Jaffe ES, Fletcher CD. Extranodal histiocytic sarcoma: clinicopathologic analysis of 14 cases of a rare epithelioid malignancy. Am J Surg Pathol. 2004 Sep;28(9):1133-44. PMID: #15316312#

-  Copie-Bergman C, Wotherspoon AC, Norton AJ, Diss TC, Isaacson PG. True histiocytic lymphoma: a morphologic, immunohistochemical, and molecular genetic study of 13 cases. Am J Surg Pathol. 1998 Nov;22(11):1386-92. PMID: #9808131#


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