sinus histiocytosis with massive lymphadenopathy
Rosai-Dorfman disease, Destombes disease
Sinus histiocytosis with massive lymphadenopathy is an idiopathic proliferation of unique histiocytes that have vesicular nuclei and voluminous pale cytoplasm, often with emperipolesis.
Associations
Langerhans histiocytosis
autoimmune lymphoproliferative syndrome (ALPS) (#15958855#)
Localization
lymph nodes
nasal fossae (#8958550#)
retro-orbital space (#8958550#)
skin
Immunohistochemistry
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