Abnormal tau phosphorylation and deposition in neurones and glial cells is one of the major features in taupathies.

Abundant cytoplasmic inclusions consisting of aggregated hyperphosphorylated protein tau are a characteristic pathological observation in several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.

Classification

 tau protein aggregation and accumulation

• Alzheimer's disease
• Pick's disease
• frontotemporal dementia
• cortico-basal degeneration
• progressive supranuclear palsy.

 tau protein mutations

 ch. 17 linked presenile dementia
 ch. 17 linked familial frontotemporal dementia
 ch. 17 linked parkinsonism

References

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