Members
KNSL1 | KNSL2 | KNSL3 | KNSL4 | KNSL5 | KNSL6 (KIF2C) |
Function
Kinesin-related proteins (KRPs) contain a motor domain that utilizes energy released from ATP hydrolysis to move cargo along microtubules.
KRPs are a fundamental component of the machinery involved in organelle movement and are implicated in various other intracellular transport events. Chromosomal segregation is a critical intracellular transport event required for progression through the M phase of the cell cycle. This segregation is performed by the mitotic spindle, which is composed of an array of microtubules and associated KRPs. Several different families of KRPs that localize to the mitotic spindle are thought to be involved in mitosis.
Members
kinesin-like-1 (KNSL1) (10q24.1) (MIM.148761)
kinesin-like-2 (KNSL2) (6p21.3) (MIM.603763)
kinesin-like-3 (KNSL3) (6p27) (MIM.603815)
kinesin-like-4 (KNSL4) (16p11.2) (MIM.603213)
kinesin-like-5 (KSNL5) (MIM.605064)
kinesin-like-6 (KSNL6) (MIM.604538)
KIF1A (MIM.601255) (2q37)
KIF3A (MIM.604683) (5q31)
KIF5C (MIM.604593)
KIF13B (MIM.607350) (gakin) (ch.8)
KIF20A (MIM.605664)
KIFC3 (MIM.604535) (16q13-q21)