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KRPs

kinesin-related proteins, kinesin-like proteins

 
Kinesin-like proteins are microtubule-associated motors that play important roles in intracellular transport and cell division.

Members

KNSL1 KNSL2 KNSL3 KNSL4 KNSL5 KNSL6 (KIF2C)

Function

Kinesin-related proteins (KRPs) contain a motor domain that utilizes energy released from ATP hydrolysis to move cargo along microtubules.

KRPs are a fundamental component of the machinery involved in organelle movement and are implicated in various other intracellular transport events. Chromosomal segregation is a critical intracellular transport event required for progression through the M phase of the cell cycle. This segregation is performed by the mitotic spindle, which is composed of an array of microtubules and associated KRPs. Several different families of KRPs that localize to the mitotic spindle are thought to be involved in mitosis.

Members

-  kinesin-like-1 (KNSL1) (10q24.1) (MIM.148761)
-  kinesin-like-2 (KNSL2) (6p21.3) (MIM.603763)
-  kinesin-like-3 (KNSL3) (6p27) (MIM.603815)
-  kinesin-like-4 (KNSL4) (16p11.2) (MIM.603213)
-  kinesin-like-5 (KSNL5) (MIM.605064)
-  kinesin-like-6 (KSNL6) (MIM.604538)

-  KIF1A (MIM.601255) (2q37)
-  KIF3A (MIM.604683) (5q31)
-  KIF5C (MIM.604593)
-  KIF13B (MIM.607350) (gakin) (ch.8)
-  KIF20A (MIM.605664)
-  KIFC3 (MIM.604535) (16q13-q21)

-  The kinesin homepage at proWeb

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