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systemic lupus erythematosus

 

Localization

-  cutaneous lupus erythematosus

Susceptibility

-  locus 1q23: polymorphism at the C-reactive protein locus (#14645206#)
-  locus 1q31
-  locuss 1q41-q42
-  locus 2q34-q35: SLEN2
-  locus 2q37.3
-  locus 4p16-p15.2
-  locus 10q22.3: SLEN1
-  locus 11p15.5: SLEN3
-  locus 11q14
-  locus 12q24

-  Polymorphisms in the tyrosine kinase 2 gene (TYK2) (#15657875#)
-  Polymorphisms in interferon regulatory factor 5 gene (IRF5) (#15657875#)

References

-  Prokunina L, Alarcon-Riquelme M. The genetic basis of systemic lupus erythematosus--knowledge of today and thoughts for tomorrow. Hum Mol Genet. 2004 Apr 1;13 Spec No 1:R143-8. PMID: #14764622#



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