Function
Catenins mediate the connection of cadherins to actin filaments and are part of a higher order submembranous network by which cadherins are linked to other transmembrane and peripheral cytoplasmic proteins (cadherin-catenin complex).
The cadherin-catenin complex interacts with epidermal growth factor receptor EGFR (MIM.131550)
catenins are associated with the tumor suppressor protein APC (MIM.175100)
catenins are involved in signaling pathways and tumorigenesis.
Members
alpha1-catenin (CTNNA1)
alpha2-catenin (CTNNA2)
alpha3-catenin (CTNNA3)
beta-catenin (CTNNB1)
delta1-catenin (CTNND1)
delta2-catenin (CTNND2)
gamma-catenin (plakoglobin ou desmoplakin-3)