Function

Catenins mediate the connection of cadherins to actin filaments and are part of a higher order submembranous network by which cadherins are linked to other transmembrane and peripheral cytoplasmic proteins (cadherin-catenin complex).

The cadherin-catenin complex interacts with epidermal growth factor receptor EGFR (MIM.131550)

 catenins are associated with the tumor suppressor protein APC (MIM.175100)

 catenins are involved in signaling pathways and tumorigenesis.

Members

 alpha1-catenin (CTNNA1)
 alpha2-catenin (CTNNA2)
 alpha3-catenin (CTNNA3)
 beta-catenin (CTNNB1)
 delta1-catenin (CTNND1)
 delta2-catenin (CTNND2)
 gamma-catenin (plakoglobin ou desmoplakin-3)