Pathology of actin polymerization

 Lowe syndrome (mutations in the OCRL1 gene, which encodes a phosphatidylinositol 4,5 bisphosphate 5-phosphatase) (#12428211#)

References

 Huang TY, Dermardirossian C, Bokoch GM. Cofilin phosphatases and regulation of actin dynamics. Curr Opin Cell Biol. 2006 Feb;18(1):26-31. PMID: #16337782#

 Stradal TE, Scita G. Protein complexes regulating Arp2/3-mediated actin assembly. Curr Opin Cell Biol. 2006 Feb;18(1):4-10. PMID: #16343889#

 Condeelis J. How is actin polymerization nucleated in vivo? Trends Cell Biol. 2001 Jul;11(7):288-93. PMID: #11413039#

 Frischknecht F, Way M. Surfing pathogens and the lessons learned for actin polymerization. Trends Cell Biol. 2001 Jan ;11(1):30-38. PMID : #11146296#