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aneurysmal fibrous histiocytoma

 

Microscopical synopsis

-  blood-filled spaces: artefact-like clefts to cystic areas mimicking cavernous vascular channels but devoid of an endothelial lining
-  prominent haemosiderin deposition with numerous siderophages
-  giant cells
-  storiform proliferation of histiocyte-like and fibroblast-like cells in a capillary-rich stroma
-  cellular polymorphism
-  hyalinized collagen bundles surrounded by tumour cells in the periphery of the lesion
-  epidermal hyperplasia (88%) (#7607620#)
-  moderate mitotic rate

Immunochemistry

-  factor XIIIa-positive histiocytic cells (#8600785#, #12484439#)

Prognosis

-  recurrence rate: 19% (#7607620#), mean duration 2.5 years (#7607620#)
-  possible involvement of a regional lymph node (#7607620#, #10874670#)

References

-  Calonje E, Fletcher CD. Aneurysmal benign fibrous histiocytoma: clinicopathological analysis of 40 cases of a tumour frequently misdiagnosed as a vascular neoplasm. Histopathology. 1995 Apr;26(4):323-31. PMID: #7607620#



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