Microscopical synopsis
blood-filled spaces: artefact-like clefts to cystic areas mimicking cavernous vascular channels but devoid of an endothelial lining
prominent haemosiderin deposition with numerous siderophages
giant cells
storiform proliferation of histiocyte-like and fibroblast-like cells in a capillary-rich stroma
cellular polymorphism
hyalinized collagen bundles surrounded by tumour cells in the periphery of the lesion
epidermal hyperplasia (88%) (#7607620#)
moderate mitotic rate
Immunochemistry
factor XIIIa-positive histiocytic cells (#8600785#, #12484439#)
Prognosis
recurrence rate: 19% (#7607620#), mean duration 2.5 years (#7607620#)
possible involvement of a regional lymph node (#7607620#, #10874670#)
References
Calonje E, Fletcher CD. Aneurysmal benign fibrous histiocytoma: clinicopathological analysis of 40 cases of a tumour frequently misdiagnosed as a vascular neoplasm. Histopathology. 1995 Apr;26(4):323-31. PMID: #7607620#