rheumatoid arthritis
Rheumatoid arthritis is a chronic inflammatory joint disease with a complex etiology in which environmental factors within a genetically susceptible host maneuver the innate and adaptive arms of the immune system toward recognition of autoantigens.
Rheumatoid arthritis (RA) is the most common systemic autoimmune disease, affecting 1% of the adult population worldwide, with an estimated heritability of 60%.
Susceptibility gene
HLA-DRB1
I kappa BL (MHC class III region) (#12509789#)
missense single-nucleotide polymorphism in PTPN22 gene encoding a protein tyrosine phosphatase (#15208781#)
References
Weyand CM, Goronzy JJ. Stem cell aging and autoimmunity in rheumatoid arthritis. Trends Mol Med. 2004 Sep;10(9):426-33. PMID: #15350894#
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