Synopsis

Variants

 pigmented hepatic adenoma (1)
 multiple hepatic adenoma (hepatic adenomatosis)

Associations

 oral contraceptive steroids
 non-contraceptive estrogens (e.g. danazol)
 virilizing and feminizing ovarian tumors
 endogenous sex steroids
 Klinefelter syndrome
 antiestrogens (e.g. clomiphene citrate)
 anabolic steroids/androgenic steroids
 carbamezepine
 severe combined immunodeficiency (SCID)
 glycogenoses

• type Ia glycogenosis
• type III glycogenosis

 Hurler disease
 familial diabetes mellitus (bi-allelic inactivation of HNF1 (TCF1))
 beta-thalassemia

Molecular biology

 bi-allelic inactivation of HNF1 (TCF1) in hepatic adenomas (#12355088#)

Differential diagnosis

 nodular regenerative hyperplasia (NRH)
 focal nodular hyperplasia (FNH)
 well-differentiated hepatocellular carcinoma

References