mantle cell lymphoma
Immunophenotype
Pan-B +
CD5+
CD23-
CD10-/+
sIgM+ bright
Putative cell of origin: CD5+ B-cells of the follicle mantle having germline IgV gene sequences
Cytogenetics
translocation t(11;14)(q13;q32) with CCND1 rearrangement with cyclin-D1 overexpression (50-90%) (11q13 and 14q32)
translocation t(1;12)(p21;q23)
complex karyotype
- complex karyotype carries an unfavourable prognostic significance
Variants
Burkitt lymphoma transformation of mantle cell lymphoma (15370262)
Cyclin D1 and t(11;14)-mantle cell lymphoma resembling marginal zone B-cell lymphoma (17316759)
composite splenic marginal zone lymphoma and mantle cell lymphoma (17134739)
Localization
nodal mantle cell lymphoma
Molecular biology
cyclin D1 overexpression by CCND1 gene secondary to the translocation t(11;14)(q13;q32) (11q13 and 14q32)
References
Mansoor A, Akbari M, Auer I, Lai R. Cyclin D1 and t(11;14)-positive B-cell neoplasms resembling marginal zone B-cell lymphoma: a morphological variant of mantle cell lymphoma. Hum Pathol. 2007 Feb 19; PMID: 17316759
Kurtin PJ. Mantle cell lymphoma. Adv Anat Pathol. 1998 Nov;5(6):376-98. PMID: 10095879