t(10;11)(p13-14;q14)
The t(10;11)(p13-14;q14) is a rare but recurring translocation associated with acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML).
Molecular biology
PICALM/MLLT10 (CALM/AF10) fusion gene by t(10;11)(p13-14;q14-21) (10554802)
The t(10;11)(p13-14;q14-21) is a recurring translocation associated with T-cell acute lymphoblastic leukemia (ALL). This translocation has also been reported in monocytic leukemia or ALL with a very early pre-B phenotype.
T-cell acute lymphoblastic leukemia (ALL)
monocytic leukemia
very early pre-B acute lymphoblastic leukemia (very early pre-B ALL)
References
Related Articles, LinksNarita M, Shimizu K, Hayashi Y, Taki T, Taniwaki M, Hosoda F, Kobayashi H, Nakamura H, Sadamori N, Ohnishi H, Bessho F, Yanagisawa M, Ohki M. Consistent detection of CALM-AF10 chimaeric transcripts in haematological malignancies with t(10;11)(p13;q14) and identification of novel transcripts. Br J Haematol. 1999 Jun;105(4):928-37. PMID: 10554802
Kobayashi H, Hosoda F, Maseki N, Sakurai M, Imashuku S, Ohki M, Kaneko Y.Hematologic malignancies with the t(10;11) (p13;q21) have the same molecular event and a variety of morphologic or immunologic phenotypes.Genes Chromosomes Cancer. 1997 Nov;20(3):253-9. PMID: 9365832 [PubMed - indexed for MEDLINE]