Multiple endocrine neoplasia type IIA (MEN2A) is an autosomal dominant syndrome of multiple endocrine neoplasms, including medullary thyroid carcinoma, pheochromocytoma, and parathyroid adenomas.
Synopsis
medullary thyroid carcinoma (MTC)
bilateral pheochromocytomas
primary hyperparathyroidism
adrenal ganglioneuroma (15827098)
Hirschsprung disease (digestive aganglionosis)
cutaneous lichen amyloidosis
Cushing syndrome
hypertension
C-cell hyperplasia
parathyroid adenoma
Etiology
germline RET mutations
Associations
renal dysplasia
References
Marx SJ. Molecular genetics of multiple endocrine neoplasia types 1 and 2. Nat Rev Cancer. 2005 May;5(5):367-75. PMID: 15864278