Leukemias
Types
acute leukemias
chronic leukemias
Classification
lymphoid leukemias
- acute lymphocytic leukemias (ALL)
- T-cell acute lymphocytic leukemia
- mature B-cell leukemias
- T/NK cell-leukemias
- T-cell large granular lymphocyte leukemia
- T-cell prolymphocytic leukemia
myeloid leukemias
- acute non lymphocytic leukemias (ANLL)
-
acute myeloid leukemias
- M0 acute non lymphocytic leukemia (M0-ANLL)
- M6 acute erythroid leukemia
- M7 acute non lymphocytic leukemia (M7-ANLL) (acute myelofibrosis)
- acute basophilic leukemia
- acute megakaryoblastic leukemia (AMegL)
-
acute myeloid leukemias
biphenotypic acute leukemia (BAL)
systemic mast cell disease (SMCD)
Human leukemia cells containing characteristic chromosomal translocations and inversions have been instrumental in identifying fusion genes implicated in the pathogenesis of the corresponding leukemia.
Although chimeric fusion genes usually provide early and essential steps in the development of leukemia, they are not in themselves sufficient, requiring additional genetic events. The nature of these secondary, cooperating genetic events is not known.
See also:
congenital leukemias (neonatal leukemias)
infant leukaemias
References
Gilliland DG, Jordan CT, Felix CA. The molecular basis of leukemia. Hematology (Am Soc Hematol Educ Program). 2004;:80-97. PMID: 15561678
Greaves MF, Wiemels J. Origins of chromosome translocations in childhood leukaemia. Nat Rev Cancer. 2003 Sep;3(9):639-49. PMID: 12951583
Staudt LM. Molecular diagnosis of the hematologic cancers. N Engl J Med. 2003 May 1;348(18):1777-85. PMID: 12724484
Bohlander SK. Fusion genes in leukemia: an emerging network. Cytogenet Cell Genet. 2000;91(1-4):52-6. PMID: 11173830
